FREQUENCY OF EJACULATORY DISORDERS ASSOCIATED WITH TAMSULOSIN THERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Abstract

Introduction: Benign prostatic hyperplasia (BPH) is very common condition in elderly male. BPH, overactive bladder, urinary tract infection, tumors, stones, or functional problems of the lower urinary tract are some of the conditions that can cause LUTS. α 1-Adrenoceptor antagonists are routinely used to treat BPH, and urologists are familiar with their safety profiles. It has been noticed that many patients having LUTS due to BPH also experience ED, causing problems in their sexual life but this aspect has been ignored many times by urologists, which adds to the patient burden. Despite the good tolerability of this drug, it still has got high chance of ED. So this study was designed to determine the frequency of ejaculatory dysfunction in our population.

Material & Methods: It’s a descriptive cross-sectional study; conducted in the department of Urology Lady Reading Hospital Peshawar from 1st January 2022 to 31st December 2022. All adult male patients presented to Urology OPD with Lower Urinary Tract Symptoms were included in the study. After a detail history, examination including digital rectal examination (DRE) and investigations like Urine routine examination, urine culture, serum PSA, renal function tests and Ultrasound Kidney, Ureter, Bladder, Prostate and Pre and Post void residual urine the patients were advised alpha adrenergic receptors blocking agents like  Tamsulosin 0.4 mg OD at night. Erectile dysfunction was assessed of all patients before starting therapy and after two 2 months. Retrograde ejaculation was assessed by taking the history from the patient and examining first voided urine after ejaculation for spermatozoa.

Results: Total of 111 patients were included in the study. Mean age was 52 years with a standard deviation ± 7.28. Ejaculatory disorders were observed in 72(65%) patients while 21(19%) patients had erectile dysfunction.

Conclusion: The frequency of ejaculatory disorders associated with tamsulosin therapy for BPH was 65%, and erectile dysfunction was observed in 19% of the patients.